3 edition of Dendritic Cells in Fundamental and Clinical Immunology found in the catalog.
|LC Classifications||June 30, 1993|
|The Physical Object|
|Pagination||xvi, 84 p. :|
|Number of Pages||47|
nodata File Size: 9MB.
12 Department of Biochemistry and Molecular Biology, School of Basic Medicine, Faculty of Medicine, Yangtze University, Jingzhou, 434023, Hubei, China. Accordingly, this strategy is under investigation in a clinical trial NCT02410733 for patients with advanced melanoma. However, because of the difficulty of obtaining large numbers of these cells by non-invasive methods, therapeutic approaches using DC became possible only after methods for the in vitro generation of these cells were described.
Among them, are regulatory T cells Treg and T helper Th subsets, which include Th1, Th2, and Th17 cells. HSC, hematopoietic stem cell; MP, myeloid precursors; LP, lymphoid precursors; MDP, macrophage-DC precursors; CDP, common DC precursors; pre-cDC, pre-classical dendritic cells; pDC, plasmacytoid dendritic cells; cDCs, conventional dendritic cells; FLT3, Fms-Related Tyrosine Kinase 3.
Though after the tumor was surgically removed, the patient's mo-DC already regained some activity, their T lymphocyte-stimulating activity reached healthy controls' levels only after the patient was submitted to treatment with a dendritic cell-based cancer vaccine. Strategies that involve the induction of a poly-antigenic response can be used to avoid this resistance, especially in melanoma, where this effect is frequently observed. All three subtypes of DC can be differentiated by their signature transcription factors and also by the expression of specific surface markers.
At this meeting it has been shown that large quantities of DC can be generated from precursors in both mice and humans, and this possibility has enormously encouraged studies aimed to characterize DC physiology and DC-specific genes, and to employ DC therapeutically as adjuvants for im munization. 1 Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Recent technologies, such as single cell RNAseq, are allowing a better characterization of DC ontogeny and the identification of DC subset precursors in peripheral blooddemonstrating that the commitment with a DC subset may be an early event, both in mice and humans.
Leone DA, Rees AJ, Kain R. Much of this effect was shown to be due to DC activation followed by the generation of T cell responses. DC are professional antigen presenting cells that both initiate and modulate the immune response.
4 Department of Gynaecology, Comprehensive Cancer Center, Hannover Medical Dendritic Cells in Fundamental and Clinical Immunology, 30625, Hannover, Germany. 2 Once differentiated, DC activation can be accomplished by using different stimuli, most of them associated with tissue damage, inflammation or the presence of a pathogen.
For this, bulk tumor products or selected tumor antigens have been used. Accordingly, IDO inhibition has shown positive effects in murine models of pancreatic cancer and a study combining IDO inhibitors with DC vaccines for breast cancer patients has completed recruitment NCT01042535.
Indeed, experimental settings targeting these molecules were able to induce T cell responsesand regression of metastatic melanoma in mice. This review will present general aspects of the DC physiology and classification and will address their potential and actual uses in the management of human disease, more specifically cancer, as therapeutic and monitoring tools. This subset of DC is phenotypically distinct in mice and humans. These fused cells express MHC molecules from both tumor and DC origin, forsaking the need of a MHC-matched donor to generate the mo-DC.
a Antigen recognition and internalization into the early endosome through specific phagocytosis microautophagy and chaperone-mediated autophagy or non-specific macropinocytosis.
11 Laboratory of Oncology, Center for Molecular Medicine, School of Basic Medicine, Faculty of Medicine, Yangtze University, 1 Nanhuan Road, Jingzhou, 434023, Hubei, China.
13 State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.
Nonetheless, the consideration of such a heterogeneous group of substances is enough to realize that adjuvant research is a rich field that may broaden the applicability and enhance the effectiveness of DC-based vaccination.
In addition to tumor lysates, living tumor cells, necrotic debris, apoptotic bodies and tumor-derived exosomes have been used.